ZIKV-IN-2

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ZIKV-IN-2

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CAS NO:

910582-16-0

ZIKV-IN-2 (compound 3a) 是一种有效的 ZIKV NS5 甲基转移酶 (MTase) 抑制剂，其IC₅₀值为 38.86 μM。ZIKV-IN-2 抑制 ZIKV 的复制和感染。ZIKV-IN-2 可用于寨卡病毒 (ZIKV) 的研究。

生物活性

ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5methyl transferase (MTase)inhibitor with anIC₅₀value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication andinfection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV)^[1].

IC₅₀& Target

IC50: 38.86 μM (MTase)^[1]

体外研究
(In Vitro)

ZIKV-IN-2 (compound 3a; 0.08-50 μM) inhibits the expression of ZIKV E protein with an EC₅₀value of 6.17 μM and inhibits ZIKV replication and infection^[1].
ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells^[1].

Cell Viability Assay^[1]

Cell Line:	Vero, Huh7 and A549 cells
Concentration:	0.08, 0.4, 2, 10, and 50 μM
Incubation Time:	96 hours
Result:	Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC₅₀>200 μM to all three cell lines.

分子量

574.75

Formula

C₃₉H₄₂O₄

CAS 号

910582-16-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.