Zasocitinib

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Zasocitinib

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2272904-53-5

NDI-034858

Zasocitinib (NDI-034858) 是一种Tyk2抑制剂，靶向Tyk2的JH2结构域，结合常数 K_d<200 pM。

生物活性

Zasocitinib (NDI-034858) is aTYK2inhibitor, targetTYK2JH2domain with binding constant K_dof<200 pm^[1].

IC₅₀& Target

Tyk2 JH2 domain^[1]

体外研究
(In Vitro)

Zasocitinib (10 μM) exhibits inhibitory effect on Tyk2 and JAK by targeting Tyk2 JH1 and JAK JH1 domain with inhibition rates<50%, respectively^[1].
Zasocitinib inhibits phosphorylation induction of heterodimer complex Tyk2 /JAK2-mediated IL-12 (1.7 ng/mL) effect, with IC₅₀value of<0.1 μM in human peripheral blood mononuclear cell^[1].

Clinical Trial

分子量

460.49

性状

Solid

Formula

C₂₃H₂₄N₈O₃

CAS 号

2272904-53-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month