| CAS NO: | 2095107-57-4 |
| 生物活性 | AFM-30a is a potentprotein arginine deiminase2 (PAD2)inhibitor and has excellent PAD2-selectivity. AFM-30a binds to PAD2 with anEC50value of 9.5 μM. AFM-30a also inhibitsH3 citrullinationwith anEC50value of 0.4 μM. AFM-30a can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis[1]. | |||||||||
| IC50& Target[1] |
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| 体外研究 (In Vitro) | AFM-30a (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC50of 9.5 μM[1]. Cell Viability Assay[1]
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| 体内研究 (In Vivo) | AFM-30a suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/-transgenic mice[2]. | |||||||||
| 分子量 | 466.51 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C24H27FN6O3 | |||||||||
| CAS 号 | 2095107-57-4 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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