BMS-P5

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BMS-P5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1549811-36-0

BMS-P5 是特异性的、具有口服活性的肽精氨酸二亚胺酶 4(PAD4)的抑制剂。BMS-P5 可阻断多发性骨髓瘤诱导的 NET 形成，并延缓肿瘤进程。

生物活性

BMS-P5 is a specific and orally activepeptidylarginine deiminase 4 (PAD4)inhibitor. BMS-P5 blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model^[1].

体外研究
(In Vitro)

BMS-P5 blocks calcium ionophore-induced citrullination of histone H3^[1].
BMS-P5 is also able to inhibit formation of NETs induced by primary MM cells isolated from the BM of patients with MM^[1].

Cell Viability Assay^[1]

Cell Line:	Neutrophils.
Concentration:	10 μM and 100 μM.
Incubation Time:	30 min followed by addition of DP42 or 5TGM1 CM.
Result:	Prevented MM-induced NET formation.

体内研究
(In Vivo)

BMS-P5 (50 mg/kg, oral gavage) significantly improves survival of MM-bearing mice^[1].
BMS-P5 (50 mg/kg, oral gavage) may attenuate the presence of pro-tumorigenic proteins in the tumor microenvironment, and thus delay tumor progression^[1].

Animal Model:	Syngeneic mouse model of MM^[1].
Dosage:	50 mg/kg.
Administration:	Oral gavage, twice a day beginning on day 3 after tumor cell injection.
Result:	Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.

分子量

509.04

Formula

C₂₇H₃₃ClN₆O₂

CAS 号

1549811-36-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.