Y-27152 是 KATP (Kir6) 通道开放剂 Y-26763 的前药，是一种长效的 K+ 通道开放剂，具有较少的心动过速:对清醒状态的高血压大鼠和狗的抗高血压作用。
| Cas No. | 127408-30-4 |
| 化学名 | N-(benzyloxy)-N-((3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl)acetamide |
| Canonical SMILES | O[C@@H]1C(C)(C)OC2=C(C=C(C#N)C=C2)[C@H]1N(C(C)=O)OCC3=CC=CC=C3 |
| 分子式 | C21H22N2O4 |
| 分子量 | 366.41 |
| 溶解度 | <9.16mg/ml in DMSO |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Y-27152, a prodrug of the KATP (Kir6) channel opener Y-26763, is a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state[1][2]. References:
[1]. Nakajima T, et al. Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J Pharmacol Exp Ther. 1992 May;261(2):730-6.
[2]. Fukunari A, et al. Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur J Pharmacol. 1997 Apr 4;323(2-3):197-204. |
