Y-26763 是一种 K+ 通道开启剂和 Y-27152 的活性代谢物。
| Cas No. | 127408-31-5 |
| 化学名 | N-((3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl)-N-hydroxyacetamide |
| Canonical SMILES | O[C@@H]1C(C)(C)OC2=C(C=C(C#N)C=C2)[C@H]1N(C(C)=O)O |
| 分子式 | C14H16N2O4 |
| 分子量 | 276.29 |
| 溶解度 | DMSO: 100 mM,Ethanol: 100 mM |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Y-26763 is a K+ channel opener and active metabolite of Y-27152[1]. Y-26763 is an ATP-sensitive K+ (KATP) channel activator[2]. References:
[1]. Itoh T, et al. Effects of a newly synthesized K+ channel opener, Y-26763, on noradrenaline-induced Ca2+ mobilization in smooth muscle of the rabbit mesenteric artery. Br J Pharmacol. 1994 Jan;111(1):165-72.
[2]. Tran QTN, et al. The identification of naturally occurring labdane diterpenoid calcaratarin D as a potential anti-inflammatory agent. Eur J Med Chem. 2019 Jul 15;174:33-44. |
