DBCO-PEG12-NHS ester 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。
Cas No. | 2093934-94-0 |
分子式 | C50H71N3O18 |
分子量 | 1002.11 |
溶解度 | DMSO : 100 mg/mL (99.79 mM; ultrasonic and warming and heat to 60°C) |
储存条件 | Store at -20°C, protect from light, stored under nitrogen |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |