m-PEG12-OH 是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。m-PEG12-OH 也是一种不可降解 (non-cleavable) 的含 12 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。
| Cas No. | 2050595-03-2 |
| 分子式 | C25H52O13 |
| 分子量 | 560.67 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | m-PEG12-OH is a PEG-basedPROTAC linkerthat can be used in the synthesis of PROTACs[1]. m-PEG12-OH is also a non-cleavable 12 unit PEGADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[2]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
