9-Decyn-1-ol 是一种 PROTAC linker，属于 alkyl/ether 类，可用于合成一系列 PROTAC 分子，如 9-Decyn-1-ol 将 GDC-0068 和 Lenalidomide 偶联可合成 INY-03-041 。INY-03-041 是一种有效的选择性 PROTAC Akt 降解剂。INY-03-041 抑制 Akt1，Akt2 和 Akt3，IC50 分别为 2.0 nM，6.8 nM 和 3.5 nM。$
| Cas No. | 17643-36-6 |
| 分子式 | C10H18O |
| 分子量 | 154.25 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1]. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker[1]. |
