DBCO-PEG5-NHS ester 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类，用于合成一系列 PROTAC 分子。DBCO-PEG5-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
| Cas No. | 2144395-59-3 |
| 分子式 | C36H43N3O11 |
| 分子量 | 693.74 |
| 溶解度 | DMSO : ≥ 100 mg/mL (144.15 mM) |
| 储存条件 | Store at -20°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-basedPROTAC linkercan be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[1][2]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
