m-PEG4-Br 是可降解 (cleavable) 的 ADC linker，用于合成曲妥珠单抗 的抗体偶联药物 (ADC)。m-PEG4-Br 被置于单甲基澳瑞他汀 E (MMAE) 有效载荷的远端，以产生具有改变的亲水性，抗原结合和体外效能的 ADC。Tetraethylene glycol monotosylate 也可用作 PROTAC 的 Linker，可用于 PROTAC 的合成。$
| Cas No. | 110429-45-3 |
| 分子式 | C9H19BrO4 |
| 分子量 | 271.15 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | m-PEG4-Br is a cleavableADC linkerused in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab . m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
