Icatibant Acetate

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Icatibant Acetate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

138614-30-9

HOE 140 acetate

Icatibant acetate (HOE-140 acetate) 是有效的，特异的缓激肽 B2 受体拮抗剂，IC₅₀和K_i值分别为 1.07 nM和 0.798 nM。

生物活性

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist ofbradykinin B2 receptorwith anIC₅₀andK_iof 1.07 nM and 0.798 nM respectively^[1]^[2]^[3].

体外研究
(In Vitro)

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)^[3].

体内研究
(In Vivo)

Animal Model:	Female mice of the CBA/J (H-2^k) strain^[2].
Dosage:	0.06, 0.3, or 1.5 mg/kg.
Administration:	Subcutaneous administration twice daily.
Result:	The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening.

Clinical Trial

分子量

1364.57

性状

Solid

Formula

C₆₁H₉₃N₁₉O₁₅S

CAS 号

138614-30-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(73.28 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.7328 mL	3.6642 mL	7.3283 mL
5 mM	0.1466 mL	0.7328 mL	1.4657 mL
10 mM	0.0733 mL	0.3664 mL	0.7328 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。