CBR Agonist-2

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CBR Agonist-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CBR Agonist-2 是一种CB1激动剂 (CB1R; CB1 配体)，EC₅₀和K_i分别为 960 nM 和 970 nM。CBR Agonist-2 是一种很有前景的工具，用于研究 hCB1R 参与的内源性大麻素系统相关疾病。

生物活性

CBR Agonist-2 is aCB1agonist (CB1R;CB1ligand) with anEC₅₀and aK_iof 960 nM and 970 nM, respectively. CBR Agonist-2 is a promising tool for investigating the involvement of hCB1R in disorders associated with the endocannabinoid system^[1].

IC₅₀& Target^[1]

hCB1-R

960 nM (EC₅₀)

hCB1-R

970 nM (Ki)

体外研究
(In Vitro)

CBR Agonist-2 (10 nM-1 μM; 24 hours) induces ERK1/2 activation in a dose-dependent manner in CHO cells expressing Gαq16 and hCB₁^[1].

Western Blot Analysis^[1]

Cell Line:	CHO cells expressing Gαq16 and hCB
Concentration:	10 nM; 100 nM; 1000 nM
Incubation Time:	24 Hours
Result:	Increased dose-dependent phosphorylation of ERK1/2 (pERK1/2) after CB1R stimulation by CBR Agonist-2.

分子量

442.53

Formula

C₂₇H₂₇FN₄O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.