Sarafotoxin S6c

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Sarafotoxin S6c

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

121695-87-2

SRTX-c

Sarafotoxin S6c (SRTX-c) 是一种有效的内皮素B受体 (endothelin-B receptor) 激动剂。Sarafotoxin S6c 可引起内皮完好血管和内皮剥离血管的收缩。

生物活性

Sarafotoxin S6c (SRTX-c) is a potentendothelin-B receptoragonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels^[1].

IC₅₀& Target

Endothelin-B receptor^[1]

体内研究
(In Vivo)

Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels^[1].

Animal Model:	Male Wister rats, exposed to 10% O₂[chronic hypoxic (CH) rats] or room air (control rats) for 2 weeks^[1]
Dosage:	1 pM-1 mM
Administration:
Result:	Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident. Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels.

分子量

2515.75

Formula

C₁₀₃H₁₄₇N₂₇O₃₇S₅

CAS 号

121695-87-2

Sequence Shortening

CTCNDMTDEECLNFCHQDVIW (Disulfide bridge: Cys1-Cys15; Cys3-Cys11)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.