GRK5-IN-4

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GRK5-IN-4

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2410794-89-5

CCG-265328

GRK5-IN-4 (Compound 16d, CCG-265328) 是一种有效的选择性共价GRK5(G 蛋白偶联受体激酶 5) 抑制剂，其IC₅₀为 1.1 μM。GRK5-IN-4 对 GRK5 的选择性是 GRK2 的90倍。GRK5-IN-4 可用于心力衰竭研究。

生物活性	GRK5-IN-4 (Compound 16d, CCG-265328) is a potent and and selective covalentGRK5(G protein-coupled receptor kinase 5) inhibitor, with anIC₅₀of 1.1 μM. GRK5-IN-4 shows 90-fold selectivity over GRK2. GRK5-IN-4 can be used for heart failure research^[1].
IC₅₀& Target	IC50: 1.1 ± 0.4 μM (GRK5), 1.8 ± 2 μM (GRK6), >100 μM (GRK2)^[1]
体外研究 (In Vitro)	GRK5-IN-4 (Compound 16d) (0-4 h) displays a marked increase in apparent potency as a function of time^[1].
分子量	483.52
Formula	C₂₆H₂₅N₇O₃
CAS 号	2410794-89-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.