Acazicolcept

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Acazicolcept

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2797026-97-0

ALPN-101

Azacicolcept (ALPN-101) 是一种 Fc 融合蛋白，是一种双重诱导型 T 细胞共刺激物 (ICOS)/CD28拮抗剂。Azacicolcept 具有抗炎活性。

生物活性

Acazicolcept (ALPN-101), an Fc fusion protein, is a dualinducible T cell costimulator (ICOS)/CD28antagonist. Acazicolcept has anti-inflammatory activities^[1].

体内研究
(In Vivo)

Azacicolcept (267-400 μg/mouse; i.p.; twice a week; for 6 weeks) 可减少皮肤和肺纤维化并缓解肺动脉高压^[1]。

Animal Model:	Six-week-old female BALB/c mice induced by hypochlorous acid (HOCL)^[1]
Dosage:	267 μg/mouse and 400 μg/mouse
Administration:	i.p.; twice a week; for 6 weeks
Result:	Induced a significant decrease in dermal thickness, collagen content, myofibroblast number, and inflammatory infiltrates characterized by B cells, T cells, neutrophils, and macrophages.

CAS 号

2797026-97-0

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.