Reltecimod (AB-103) 是一种 T 细胞特异性表面糖蛋白 CD28 (TP44) 拮抗剂。Reltecimod对不同的细菌感染、细菌外毒素和内毒素以及电离辐射都有良好的抗性作用。Reltecimod 通过靶向和减弱关键的 CD28/B7-2 共刺激通路来调节炎症反应，而不抑制它。Reltecimod 可用于研究坏死性软组织感染 (NSTIs)。
| 生物活性 | Reltecimod (AB-103) is aT-cell-specific surfaceglycoproteinCD28 (TP44)antagonist. Reltecimod has beneficial effects against differentbacterialinfections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs)[1][2]. |
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体内研究
(In Vivo) | Reltecimod (1.25-5 mg/kg; i.v.) increases the survival rate of mice infected with different bacteria[2].
| Animal Model: | Pathogen-free, female BALB/c mice (Acute bacterial peritonitis was induced by i.p. administration withE. coli018:K1)[2] | | Dosage: | 1.25 or 5 mg/kg | | Administration: | i.v.; single dosage; at 4 h post infection | | Result: | Resulted in 100% survival at single dosage of 5 mg/kg, at day 6.
Resulted in 70% survival at 4 dosage (at 1, 12, 24 and 36 h post infection) of 1.25 mg/kg, at day 6. |
| Animal Model: | Pathogen-free, female BALB/c mice (NSTI induced by thigh i.m. administration withStreptococcus pyogenes)[2] | | Dosage: | 2.5 or 5 mg/kg | | Administration: | i.v.; single dosage; at 1 h, or at 1 h and 12 or 72 h post infection | | Result: | Resulted in 65% survival at single dosage of 2.5 mg/kg, at day 8.
Resulted in 30% survival at two dosage (1 and 12 h post infection) of 2.5 mg/kg, at day 8.
Resulted in 90% survival at single dosage (1 h post infection) of 5 mg/kg, at day 6. |
| Animal Model: | Pathogen-free, female BALB/c mice [Cecal ligation and puncture (CLP) model][2] | | Dosage: | 1.25, 2.5, or 5 mg/kg | | Administration: | i.v.; single dosage | | Result: | Increased day 7 survival by up to 100%. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
