Raleukin

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Raleukin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

143090-92-0

阿那白滞素
AMG-719

Raleukin (AMG-719) 是重组的、非溶酶化的白细胞介素-1受体 (IL-1R)的拮抗剂。Raleukin (AMG-719) 是第一个用于阻断促炎作用的生物制剂。

生物活性

Raleukin (AMG-719) is a recombinant, nonglycosylated humaninterleukin-1 receptor (IL-1R)antagonist. Raleukin (AMG-719) is the first biological agent to block the pro-inflammatory effects^[1]^[2].

IC₅₀& Target

IL-1

体内研究
(In Vivo)

Combined Etanercept (5 mg/kg, ip) and Anakinra (100 mg/kg, ip. daily for 7 days) substantially improves marginal mass human islet engraftment in immunodeficient mice^[2].
Raleukin (AMG-719) enhances tumor growth inhibition in mice receiving peptide vaccination and β-(1-3),(1-6)-D-glucan^[3].

Clinical Trial

分子量

17257.60

性状

Liquid

Formula

C₇₅₉H₁₁₈₆N₂₀₈O₂₃₂S₁₀

CAS 号

143090-92-0

中文名称

阿那白滞素

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.