CAS NO: | 851095-32-4 |
生物活性 | STX-0119 is a selective, orally activeSTAT3dimerization inhibitor. STX-0119 inhibitsSTAT3transcription with anIC50of 74 μM[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | STX-0119 (10-50 μM; 24 h) inhibits STAT3 dimerization through a direct interaction with the STAT3 protein and not via the modulation of upstream regulators such as JAK in HEK293 and MDA-MB-468 cells[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | STX-0119 (160 mg/kg; oral gavage; daily for 4 days) inhibits SCC-3 tumor growth in mice[1].
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分子量 | 382.37 | ||||||||
性状 | Solid | ||||||||
Formula | C22H14N4O3 | ||||||||
CAS 号 | 851095-32-4 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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