InsulinDetemir is an artificialinsulin, shows effect on controlling blood sugar levels.InsulinDetemir stimulatesGLP-1secretion as a consequence of enhanced Gcg expression by a mechanism involving activation ofAkt- and/or extracellular signal-regulated kinase (ERK)-dependent-cat and CREB signaling pathways.InsulinDetemir can be used for type 2 diabetes research^[1][2].

Insulin Detemir (d-INS) (100 nM; 0.5-4 h) increases Gcg mRNA expression in primary fetal rat intestinal cell (FRIC) cultures, and (100 nM; 5 min and 10 min) induces rapid phosphorylation of Akt, as well^[1].
Insulin Detemir (100 nM; 5-120 min) increases β-catenin phosphorylation, its nuclear translocation, and enhances cAMP response element-binding protein (CREB) phosphorylation in a phosphatidylinositol 3-kinase and/or mitogen-activated protein kinase kinase/extracellular signal-regulated kinase-sensitive manner^[1].

Insulin Detemir (d-INS) (5 IU/kg; i.p.; once daily; 2 weeks) demonstrates weight-sparing effects compared with other insulin formulations, and shows a intestinal tissues preference, potentially involving the activation of insulin/-catenin/CREB signaling pathways^[1].

Liquid

C₂₆₇H₄₀₂N₆₄O₇₆S₆

169148-63-4

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