Sugiol

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Sugiol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

511-05-7

(+)-Sugiol
10-Deoxoxanthoperol

Sugiol 是一种枞烷二萜，可从台湾板栗树 (Calocedrus formosana) 的树皮中分离出来。Sugiol 具有抗炎活性，可有效减少脂多糖 (LPS) 刺激巨噬细胞后的活性氧 (ROS) 产生。

生物活性

Sugiol is an abietane diterpenoid, can be isolated fromCalocedrus formosanabark. Sugiol has anti-inflammatory activity, could effectively reduce intracellularreactive oxygen species(ROS) production in lipopolysaccharide (LPS)-stimulated macrophages^[1].

IC₅₀& Target^[1]

ERK1

ERK2

p38 MAPK

JNK1

JNK2

IL-1β

体外研究
(In Vitro)

Sugiol (5-30 μM; 30 min) 抑制 J774A 细胞中 TNF-α 和 proIL-1β/IL-1β 蛋白的产生^[1]。
Sugiol (5-30 μM; 30 min) 在脂多糖诱导的 J774A 细胞中抑制 MAPK 激活，抑制 ERK1/2, JUNK1/2 和 p38 磷酸化^[1]。

Western Blot Analysis^[1]

Cell Line:	J774A.1 macrophages cells stimulated with LPS
Concentration:	5 μM, 10 μM, 20 μM, and 30 μM
Incubation Time:	30 min
Result:	Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation.

分子量

300.44

Formula

C₂₀H₂₈O₂

CAS 号

511-05-7

结构分类

Terpenoids
Diterpenoids

来源

Plants
Cupressaceae
Calocedrus formosana(Florin) Florin

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.