CID 5951923

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CID 5951923

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CAS NO:

749872-43-3

CID 5951923是一种有效的Krüppel-like factor 5 (KLF5)抑制剂，IC₅₀值为 603 nM，CID 5951923 可在体外抑制癌细胞的增殖。

生物活性

CID 5951923 is a potent inhibitor ofKrüppel-like factor 5 (KLF5), with anIC₅₀of 603 nM. CID 5951923 can inhibit proliferation ofcancercells in vitro^[1].

IC₅₀& Target

IC50: 603 nM (KLF5)^[1]

体外研究
(In Vitro)

CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner^[1].
CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY¹⁰⁶⁸, and downregulated EGR1^[1].
CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells^[1].

Cell Viability Assay^[1]

Cell Line:	DLD-1 and IEC-6 cells
Concentration:	0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time:	48 h
Result:	Inhibited proliferation of DLD-1 cells with an IC₅₀of 1.6 μM.

分子量

382.39

Formula

C₁₆H₁₈N₂O₇S

CAS 号

749872-43-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.