RET-IN-19

立即咨询

RET-IN-19

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2484919-71-1

RET-IN-19 (compound 59) 是一种有效的RET抑制剂，对RET-wt和RET V804M的IC₅₀值分别为 6.8 和 13.51 nM。RET-IN-19 具有抗癌活性。RET-IN-19 可用于非小细胞肺癌 (NSCLC) 研究。

生物活性

RET-IN-19 (compound 59) is a potentRETinhibitor, withIC₅₀values of 6.8 and 13.51 nM againstRET-wtandRETV804M, respectively. RET-IN-19 shows anticancer activity. RET-IN-19 can be used for non-small cell lungcancer(NSCLC) research^[1].

IC₅₀& Target

EGFR

56.78 ± 4. μM (IC₅₀)

Aurora A

0.242 ± 0. μM (IC₅₀)

Aurora B

0.536 ± 45 μM (IC₅₀)

MAP4K4

3.428 ± 0. μM (IC₅₀)

体外研究
(In Vitro)

RET-IN-19 (compound 59) shows growth inhibition of LC-2/ad cells which RET-CCDC6 driven, with a GI₅₀of 0.1067 ± 0.004 μM^[1].
RET-IN-19 (3 μM) shows inhibition of LC-2/ad cells migration^[1].
RET-IN-19 inhibits EGFR, Aurora A, Aurora B, Nek2, CSF-1R, MAP4K4, NIK, and RET, with IC₅₀values of 56.78 ± 4.94, 0.242 ± 0.036, 0.536 ± 45.12, >200, 1.65 ± 0.235, 3.428 ± 0.150, >10, and 0.0068 ± 0.0003, respectively^[1].

分子量

544.62

Formula

C₂₈H₂₈N₆O₄S

CAS 号

2484919-71-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.