GNE 220

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GNE 220

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1199590-75-4

GNE-220 是一种有效的选择性MAP4K4抑制剂，IC₅₀为 7 nM。

生物活性

GNE-220 is a potent and selective inhibitor ofMAP4K4with anIC₅₀of 7 nM.

IC₅₀& Target

MAP4K4

7 nM (IC₅₀)

MAP4K5

9 nM (IC₅₀)

MAP4K6

1.1 μM (IC₅₀)

体外研究
(In Vitro)

GNE-220 also inhibits a few other kinases with IC₅₀s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM⁺retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1⁺long focal adhesions (FAs)^[1].

分子量

438.53

Formula

C₂₅H₂₆N₈

CAS 号

1199590-75-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.