(E/Z)-Necrosulfonamide

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CAS NO:

432531-71-0

MLKL药理抑制剂(NECROSULFONAMIDE)

(E/Z)-Necrosulfonamide 是 Necrosulfonamide (HY-100573) 的消旋体。Necrosulfonamide，一种necroptosis抑制剂，通过选择性靶向(MLKL)。Necrosulfonamide 阻止 MLKL-RIP1-RIP3 坏死小体复合体与其下游效应子相互作用。MLKL 是诱导坏死过程中 RIP3 的重要底物。

生物活性	(E/Z)-Necrosulfonamide is a racemic compound ofNecrosulfonamide(HY-100573). Necrosulfonamide is anecroptosisinhibitor acting by selectively targeting themixed lineage kinasedomain-like protein(MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis^[1]^[2].
分子量	461.47
Formula	C₁₈H₁₅N₅O₆S₂
CAS 号	432531-71-0
中文名称	MLKL药理抑制剂(NECROSULFONAMIDE)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.