Maralixibat chloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

228113-66-4

SHP625 chloride
LUM001 chloride
Lopixibat chloride

Maralixibat (SHP625) chloride 是一种口服活性回肠胆汁酸转运体(IBAT)抑制剂。(IBAT) 可用于治疗罕见的胆汁淤积性肝病，包括 Alagille 综合征 (ALGS)、进行性家族性肝内胆汁淤积症 (PFIC) 和胆道闭锁。

生物活性

Maralixibat (SHP625) chloride is an orally activeileal bile acid transporter (IBAT)inhibitor. Maralixibat chloride can be used for the treatment of rare cholestatic liver diseases including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC) and biliary atresia^[1]^[2].

体内研究
(In Vivo)

Maralixibat chloride reduces elevations in sBA levels, improves liver function, and reduces liver tissue damage, in a rat partial bile duct ligation model of cholestasis^[2].

Clinical Trial

分子量

710.41

性状

Solid

Formula

C₄₀H₅₆ClN₃O₄S

CAS 号

228113-66-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 50 mg/mL(70.38 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.4076 mL	7.0382 mL	14.0764 mL
5 mM	0.2815 mL	1.4076 mL	2.8153 mL
10 mM	0.1408 mL	0.7038 mL	1.4076 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。