264W94

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264W94

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

178961-24-5

264W94 是有效的回肠胆汁酸转运蛋白 (IBAT) 抑制剂，是新型降胆固醇药。264W94 具有 CYP7A1 诱导作用和抗血脂作用。

生物活性

264W94 is a potentileal bile acid transporter (IBAT)inhibitor and a newcholesterollowering agent. 264W94 has CYP7A1 induction, and antilipemic action^[1].

IC₅₀& Target

IBAT^[1]

体外研究
(In Vitro)

264W94 (0, 0.1, 0.25, 0.5 μM) inhibits human IBAT-specific transport of 5 μM TC by 14% to 75% in a concentration-dependent manner with IC₅₀of 0.25 μM in CHO-hIBAT cells^[1].

体内研究
(In Vivo)

264W94 (orally; 0.03-1.0 mg/kg; twice a day for 3.5 days) dose-dependently attenuates diet-induced increases in serum LDL+VLDL-C, as well as the decrease in HDL-C^[1].
264W94 (orally; 0.003, 0.01, 0.03, 0.1 mg/kg; twice a day for 2 days) increases fecal excretion of⁷⁵SeHCAT in a dose-dependent manner^[1].
264W94 (0.001, 0.01, 0.1, 1, and 10 mg/kg; twice a day for 2 weeks) reduces dose-dependently plasma glucose in male ZDF (ZDF/GmiCrl-fa/fa) rats. Treatment of 264W94 prevents the decline of insulin dose-dependently without an increase in proinsulin levels^[2].

Animal Model:	Male Sprague Dawley rats (CD, Charles River, 270-310 gm)^[1]
Dosage:	0.03, 0.1, 0.3, 1.0 mg/kg
Administration:	Orally; twice a day (9:00 am and 3:30 pm) for 3.5 days
Result:	Dose-dependently attenuated diet-induced increases in serum LDL+VLDL-C, as well as the decrease in HDL-C.

分子量

417.56

Formula

C₂₃H₃₁NO₄S

CAS 号

178961-24-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.