Venturicidin A

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Venturicidin A

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

33538-71-5

Aabomycin A1

Venturicidin A (Aabomycin A1) 可从放线菌类中得到，是一种ATP合酶抑制剂，可增强氨基糖苷类抗生素庆大霉素对葡萄球菌、肠球菌和铜绿假单胞菌的耐多药临床分离株的抵抗力。Venturicidin A对人胚胎肾 (HEK) 细胞具有明显的毒性，IC₅₀为 31 μg/mL。

生物活性

Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor ofATP synthase. Venturicidin A potentiates theaminoglycosideantibiotic gentamicin against multidrug-resistant clinical isolates ofStaphylococcus,Enterococcus, andPseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC₅₀of 31 μg/mL^[1].

IC₅₀& Target

Aminoglycoside

分子量

749.97

Formula

C₄₁H₆₇NO₁₁

CAS 号

33538-71-5

结构分类

Antibiotics
Macrolide Antibiotics

来源

actinomycetes

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.