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Ginkgolide B
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ginkgolide B图片
CAS NO:15291-77-7
包装:20mg
市场价:378元

Ginkgolide B (BN-52021) 是一种来自银杏叶的重要活性萜类化合物，据报道可增加细胞活力并减少细胞凋亡。
Cas No.15291-77-7
别名银杏内酯 B; 白果苦内酯 B; BN-52021
Canonical SMILESO=C1O[C@@]2([H])C([C@@]([C@]([C@@]3([H])OC4=O)([C@]4([H])C([H])([H])[H])O[H])1O[C@]5([H])OC6=O)(C3([H])O[H])C5([C@@]6([H])O[H])C(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])([H])C2([H])[H]
分子式C20H24O10
分子量424.4
溶解度DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 14 mg/ml
储存条件Store at 2-8℃ Dry, sealed and protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ginkgolide B (BN-52021), an important active terpenoid from Ginkgo biloba leaves, is reported to increase cell viability and decrease cell apoptosis.IC50 value:Target:In vitro: Ginkgolide B (0.2 or 0.4 μg/ml) was added to the culture medium in vitro led to increases in cell viability and decreases in the number of hippocampal cells undergoing AAPH-induced apoptosis [1]. Ginkgolide B caused a dose-related protection against dysrhythmias; the antiarrhythmic effect of ginkgolide B was comparable to that of diltiazem and superior to the activity of metoprolol. Ginkgolide B can presumably prevent the re-entry mechanism involved in the development of ischemia-induced rhythm disturbances [2].In vivo: Oral administration of ginkgolide B (2 mg/kg/day, p.o.) caused a significant increase in cell viability and a highly significant decrease in the numbers of both spontaneously occurring and AAPH-induced apoptoses.

References:
[1]. Jean R. Rapin, et al. In vitro and in vivo effects of an extract of Ginkgo biloba (EGb 761), ginkgolide B, and bilobalide on apoptosis in primary cultures of rat hippocampal neurons. Drug Development Research, 1998, 45 (1):1-43
[2]. Matyas Koltai, et al. Ginkgolide B protects isolated hearts against arrhythmias induced by ischemia but not reperfusion. European Journal of Pharmacology, 1989, 164 (2): 293-302

 
 
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