CALP1

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CALP1

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CAS NO:

145224-99-3

CALP1 是一种钙调蛋白 (CaM) 激动剂 (K_d为 88 μM)，与CaMEF-hand/Ca²⁺结合位点结合。CALP1 通过抑制钙通道 (calcium channel) 的开放来阻止钙的流入和凋亡 (IC₅₀为 44.78 μM)。CALP1 阻止谷氨酸受体 (glutamate receptor channels) 通道，并阻止存储操作的非选择性阳离子通道。CALP1 激活CaM依赖性磷酸二酯酶 (phosphodiesterase) 活性。

生物活性	CALP1 is acalmodulin(CaM)agonist (K_dof 88 μM) with binding to theCaMEF-hand/Ca²⁺-binding site. CALP1 blocks calcium influx andapoptosis(IC₅₀of 44.78 μM) through inhibition ofcalcium channelopening. CALP1 blocksglutamate receptor channelsand blocks a store-operated nonselective cation channel. CALP1 activatesCaM-dependentphosphodiesteraseactivity^[1]^[2]^[3]^[4].
IC₅₀& Target	Kd: 88 μM (Calmodulin)^[4]
分子量	842.08
Formula	C₄₀H₇₅N₉O₁₀
CAS 号	145224-99-3
Sequence	Val-Ala-Ile-Thr-Val-Leu-Val-Lys
Sequence Shortening	VAITVLVK
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.