Calmodulin antagonist-1 (W-7) 是一种钙调素(CaM)拮抗剂。Calmodulin antagonist-1抑制钙调素激活的 Ca2+-磷酸二酯酶 (IC50=28 μM)。Calmodulin antagonist-1 以竞争方式抑制胰蛋白酶处理的 Ca2+-磷酸二酯酶 (IC50=375 μM)，与cGMP 相关，Ki值为 300 μM。
| 生物活性 | Calmodulinantagonist-1 (W-7) is acalmodulin(CaM)antagonist.Calmodulinantagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=28 μM).Calmodulinantagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=375 μM) in a competitive fashion with respect to cyclic GMP and the Kivalue is 300 μM[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
