GLPG1837

立即咨询

GLPG1837

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1654725-02-6

ABBV-974

GLPG1837 是一种有效的，可逆的CFTR增强剂，对 CFTR 的突变体 F508del 和 G551D 的EC₅₀值分别为 3 nM 和 339 nM。

生物活性

GLPG1837 is a potent and reversibleCFTRpotentiator, withEC₅₀s of 3 nM and 339 nM for F508del and G551DCFTR, respectively.

IC₅₀& Target

EC50: 3 nM (F508del CFTR), 339 nM (G551D CFTR)^[1]

体外研究
(In Vitro)

GLPG1837 is a potent CFTR potentiator, with EC₅₀s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. GLPG1837 increases the conductivity of the G551D CFTR channel with obtained potency of 181 nM^[1]. GLPG1837 is reversible CFTR potentiator, with a the apparent affinity within a range of 0.2~2 μM^[2].

Clinical Trial

分子量

348.42

性状

Solid

Formula

C₁₆H₂₀N₄O₃S

CAS 号

1654725-02-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 250 mg/mL(717.52 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.8701 mL	14.3505 mL	28.7010 mL
5 mM	0.5740 mL	2.8701 mL	5.7402 mL
10 mM	0.2870 mL	1.4350 mL	2.8701 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。