Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identifyCa²⁺-activated Cl^-currents(CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells^[1].

Ca²⁺-activated Cl^-currents^[1]

Anthracene-9-carboxylic acid causes a voltage-dependent block of outward currents in HEK 293T cells and inhibits a larger fraction of the current as depolarization increased^[1].
Anthracene-9-carboxylic acid induces a strong potentiation of tail currents measured at -100 mV after depolarizing voltages, as well as a prolongation of the deactivation kinetics in HEK 293T^[1].
Anthracene-9-carboxylic acid (500 μM, rabbit pulmonary artery smooth muscle cells) produces a small inhibition of the maximum outward Cl^-current at +70 mV (21±10%) but augmented the amplitude of the instantaneous inward relaxation at -80 mV by 321±34%^[2].

222.24

Solid

C₁₅H₁₀O₂

723-62-6

Room temperature in continental US; may vary elsewhere.