5J-4

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5J-4

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	827001-82-1
包装:	10mg
市场价:	1650元

5J-4 是一种有效的CRAC抑制剂。5J-4 减少了浸润到 CNS 中的单核细胞的数量，并显着减少浸润的 CD4+ 细胞。5J-4 可减轻炎症小鼠模型中 EAE (实验性自身免疫性脑脊髓炎) 的症状并延缓其发作。

生物活性

5J-4 is a potentCRACinhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation^[1].

体内研究
(In Vivo)

5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt^[1].
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE^[1].

Animal Model:	C57BL/6 mice (MOG35-55 peptide-immunized mice)^[1]
Dosage:	2 m/kg
Administration:	I.p., every alternate day for 30 days
Result:	Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.

分子量

312.34

性状

Powder

Formula

C₁₆H₁₂N₂O₃S

CAS 号

827001-82-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month