Leptomycin A 是链霉菌的代谢物，是CRM1的抑制剂，阻断CRM1和核出口信号相互作用，阻止多种蛋白质的核出口。Leptomycin A 抑制 HIV-1的复制。活性略低于 Leptomycin B。
| 生物活性 | Leptomycin A, a Streptomyces metabolite, is an inhibitor ofCRM1(exportin 1)that blocksCRM1interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppressesHIV-1replication. Less potent than Leptomycin B[1][2]. |
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| 结构分类 | - Antibiotics
- Other Antibiotics
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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