| CAS NO: | 5614-64-2 |
| 包装: | 5mg |
| 市场价: | 1710元 |
| Cas No. | 5614-64-2 |
| 别名 | 2-氨基-6,8-二羟基嘌呤 |
| Canonical SMILES | O=C1NC(N)=NC2=C1NC(N2)=O |
| 分子式 | C5H5N5O2 |
| 分子量 | 167.13 |
| 溶解度 | Water:< 0.1 mg/mL (insoluble); Ethanol:< 1 mg/mL (insoluble); DMSO:< 1 mg/mL (insoluble or slightly soluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions. Human Endogenous Metabolite [1]. Arai T, et al. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002 Dec;23(12):2005-10. [2]. Floyd RA, et al. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 1990 Sep;11(9):1447-50. [3]. Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72. |
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