WAY-213613 is a potent and selectivehumanEAAT2inhibitor. WAY-213613 has potentEAAT2inhibitory activity with anIC₅₀value of 85 nM. WAY-213613 can be used for the research of central nervous system^[1][2]

IC50: 5004 nM (EAAT1); 85 nM (EAAT2); 3787 nM (EAAT3)^[1]

WAY-213613 (0-100 μM) has inhibitory activity for human EAAT1, EAAT2 and EAAT3 subtype with IC₅₀values of 5004 nM, 85 nM and 3787 nM, respectively^[1].
WAY-213613 (3, 30, 300 nM) has the inhibitory effect on synaptosomal L-[³H] glutamate uptake with K_ivalues of 15 nM, 41 nM and 55 nM in the presence of 3, 30 and 300 nM, respectively^[1].
WAY-213613 (0-100 μM) produces a concentration-dependent block of glutamate-induced currents in EAAT1-, EAAT2- or EAAT3-injected oocytes, with IC₅₀values of 48, 0.13 and 4.0 μM, respectively^[1].
WAY-213613 (0.5–50 μM) exhibits good selectivity over ionotropic receptors and EAAT2 and potent activity toward blocking NMDA-stimulated responses^[1].

415.19

Solid

C₁₆H₁₃BrF₂N₂O₄

868359-05-1

Room temperature in continental US; may vary elsewhere.