| CAS NO: | 1850293-95-6 |
| 包装 | 价格(元) |
| 1mg | 询价 |
| 5mg | 询价 |
| 10mg | 询价 |
| 50mg | 询价 |
| Cas No. | 1850293-95-6 |
| 别名 | Selenium-acetylsalicylic Acid |
| 化学名 | selenocyanic acid, 2-[[2-(acetyloxy)benzoyl]amino]ethyl ester |
| Canonical SMILES | O=C(C)OC1=CC=CC=C1C(NCC[Se]C#N)=O |
| 分子式 | C12H12N2O3Se |
| 分子量 | 311.2 |
| 溶解度 | ≤10mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Se-Aspirin is a novel selenium-nonsteroidal anti-inflammatory drug (Se-NSAID) [1]. NSAIDs have demonstrated intestinal antineoplastic effects in various animal intestinal cancer models. Selenium (Se) compounds have attracted a vast interest as promising chemo-preventive agents. Several epidemiological studies have reported an inverse association between the nutritional Se status and cancer risk. Se functioned as chemo-preventive agent for cancer therapy in the past few years. Se-Aspirin was a hybrid of selenium and a nonsteroidal anti-inflammatory drug. t Se-Aspirin reduced the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells with the IC50 value of 3.4 μM. Se-Aspirin inhibited the cell cycle in G1 and G2/M phases and induced apoptosis by activating caspase 3/7 and PARP cleavage. Long-term exposure to Se-Aspirin has been reported to cause an increase in intracellular reactive oxygen species levels in CRC cells [1]. Reference: |
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