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Z-Asp-CH2-DCB
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Z-Asp-CH2-DCB图片
CAS NO:153088-73-4
包装与价格：
包装价格(元)
5mg询价
10mg询价
25mg询价
50mg询价

Z-Asp-CH2-DCB 是一种不可逆的广谱 caspase 抑制剂。
Cas No.153088-73-4
别名Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone
化学名(3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester 2,6-dichloro-benzoic acid
Canonical SMILESClC1=C(C(OCC([C@@H](NC(OCC2=CC=CC=C2)=O)CC(O)=O)=O)=O)C(Cl)=CC=C1
分子式C20H17Cl2NO7
分子量454.3
溶解度≤33mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Z-Asp-CH2-DCB is an inhibitor of ICE/Ced-3 family proteases [1].

Caspases (ICE/ Ced3 proteases) play key biological roles in inflammation and mammalian apoptosis. Caspases are a closely related family of cysteine proteases that play a key role in apoptotic cell death. Activation of Caspases shows important roles in programmed cell death such as pyroptosis and necroptosis to protect cells from stress signals and pathogenic attack. Caspases play an important role in inflammation. Caspases have also been involved in cell proliferation, cell differentiation, tumour suppression, neural development and axon guidance and ageing. Deficiency in caspase results in tumour development. Overactivation of some caspases can lead to excessive programmed cell death, such as caspase-3 [2].

Z-Asp-CH2-DCB blocked apoptosis in U937 cells triggered by antitumor agents. Z-Asp-CH2-DCB also blocked apoptosis in IFN-γ-pretreated cells. Z-Asp-CH2 -DCB completely inhibited DNA fragmentation induced by γ-irradiation, antitumor agents, or anti-Fas antibody [1].

References:
[1] Tamura T, Ueda S, Yoshida M, et al.  Interferon-γ InducesIceGene Expression and Enhances Cellular Susceptibility to Apoptosis in the U937 Leukemia Cell Line[J]. Biochemical and biophysical research communications, 1996, 229(1): 21-26.
[2] Brker L E, Kruyt F A E, Giaccone G.  Cell death independent of caspases: a review[J]. Clinical Cancer Research, 2005, 11(9): 3155-3162.

 
 
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