Opiranserin

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Opiranserin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1441000-45-8

VVZ-149

Opiranserin (VVZ-149)，一种非阿片类药物和非甾体抗炎止痛药，是 2 型甘氨酸转运蛋白(GlyT2)和 5-羟色胺受体2A(5HT2A)的双重拮抗剂，IC₅₀分别为 0.86 和 1.3 μM。Opiranserin 对 rP2X3 有拮抗作用 (IC₅₀=0.87 μM)。Opiranserin 可用于术后疼痛的研究。

生物活性

Opiranserin (VVZ-149), a non-opioid and non-NSAID analgesic candidate, is a dual antagonist ofglycine transporter type 2 (GlyT2)andserotonin receptor 2A (5HT2A), withIC₅₀s of 0.86 and 1.3 μM, respectively. Opiranserin shows antagonistic activity on rP2X3 (IC₅₀=0.87 μM). Opiranserin is development as an injectable agent for the treatment of postoperative pain^[1]^[2]^[3].

IC₅₀& Target^[2]

5-HT_2AReceptor

1.3 μM (IC₅₀)

GlyT2

0.86 μM (IC₅₀)

rP2X3

0.87 μM (IC₅₀)

Clinical Trial

分子量

394.51

Formula

C₂₁H₃₄N₂O₅

CAS 号

1441000-45-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.