| CAS NO: | 374886-51-8 |
| 生物活性 | ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-activeglycine transporter-1 (GlyT1)inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease[1]. | |||||||||
| IC50& Target | GlyT1[1] | |||||||||
| 体外研究 (In Vitro) | ASP2535 potently inhibits rat GlyT1 (IC50=92 nM) with 50-fold selectivity over rat glycine transporter-2 (GlyT2) in vitro[1]. | |||||||||
| 体内研究 (In Vivo) | ASP2535 (0.3-3 mg/kg; p.o) attenuates working memory deficit in MK-801-treated mice and visual learning deficit in neonatally phencyclidine (PCP)-treated mice[1].
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| 分子量 | 382.42 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C22H18N6O | |||||||||
| CAS 号 | 374886-51-8 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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