CNQX

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CNQX

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

115066-14-3

FG9065

CNQX (FG9065) 是一种有效的竞争性 AMPA /海藻酸酯受体 (AMPA/kainate receptor) 拮抗剂，IC₅₀分别为 0.3 μM 和 1.5 μM。CNQX 是一种竞争性的非NMDA受体拮抗剂。CNQX 会阻止大鼠恐惧增强的表达。

生物活性

CNQX (FG9065) is a potent and competitiveAMPA/kainate receptorantagonist withIC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitivenon-NMDA receptorantagonist^[1]. CNQX blocks the expression of fear-potentiated startle in rats^[5].

IC₅₀& Target

IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)^[1]

体外研究
(In Vitro)

CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices^[2].
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments^[3].

体内研究
(In Vivo)

Animal Model:	Male Wistar rats weighing 180-200 g^[4]
Dosage:	0.75, 1.5, and 3 mg/kg
Administration:	IP; 20 min before testing
Result:	Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval

分子量

232.15

性状

Solid

Formula

C₉H₄N₄O₄

CAS 号

115066-14-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 20 mg/mL(86.15 mM;Need ultrasonic)

H₂O :< 0.1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	4.3076 mL	21.5378 mL	43.0756 mL
5 mM	0.8615 mL	4.3076 mL	8.6151 mL
10 mM	0.4308 mL	2.1538 mL	4.3076 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。