Valbenazine tosylate (NBI-98854 tosylate) 是一种囊泡单胺类转运 2 (VMAT2) 抑制剂，Ki为 110-190 nM。
| 生物活性 | Valbenazine tosylate (NBI-98854 tosylate) is a vesicularmonoamine transporter2 (VMAT2) inhibitor with theKiof 110-190 nM[1]. |
体外研究
(In Vitro) | Valbenazine exhibits VMAT2 binding affinity in rat striatum and human platelets with Kis of 110 and 150 nM, respectively[1].
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体内研究
(In Vivo) | Valbenazine (10 mg/kg; orally) induces ptosis (primarily an adrenergic response) and increases plasma prolactin primarily a dopaminergic response in rats[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
