Benzamil

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Benzamil

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2898-76-2

Benzylamiloride

Benzamil (Benzylamiloride)，是 Amiloride 类似物，是一种 Na⁺/Ca²⁺交换体(NCX)抑制剂，(IC₅₀~100 nM)。Benzamil 也是一种非选择性Deg/epithelial sodium channels (ENaC)阻滞剂，能增强肌源性血管收缩。Benzamil 抑制 TRPP3 介导的 Ca²⁺激活电流，IC₅₀为 1.1 μM。

生物活性	Benzamil (Benzylamiloride), an Amiloride analogue, is aNa⁺/Ca²⁺exchanger (NCX)inhibitor (IC₅₀~100 nM). Benzamil also is a non-selectiveDeg/epithelial sodium channels (ENaC)blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca²⁺-activated currents, with an IC₅₀of 1.1 μM^[1]^[2]^[3].
体外研究 (In Vitro)	Benzamil (Benzylamiloride) inhibits neuronal and heterologously expressed small conductance Ca²⁺-activated K²⁺channels^[4].
体内研究 (In Vivo)	Benzamil (Benzylamiloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats^[5].
分子量	319.75
Formula	C₁₃H₁₄ClN₇O
CAS 号	2898-76-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.