hACC2-IN-1

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hACC2-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

192323-14-1

hACC2-IN-1 是一种有效的乙酰辅酶 A 羧化酶 2 (ACC2) 抑制剂，IC₅₀为 2.5 μM (hACC2)。hACC2-IN-1 可能用于肥胖研究。

生物活性

hACC2-IN-1 is a potentacetyl-CoA carboxylase2(ACC2) inhibitor, with anIC₅₀value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research^[1].

IC₅₀& Target

hACC2

2.5 μM (IC₅₀)

体外研究
(In Vitro)

ACC2 isoform, presents on the mitochondrial surface, inhibits carnitine palmitoyl transferase 1 (CPT-1) and converts acetyl-CoA into malonylCoA for de novo lipogenesis in the cytosol^[1].
ACCs inhibition will change cellular substrate and favour lipid oxidation, thus preventing deleterious lipids from accumulating in oxidative tissue such as muscle, heart and liver^[1].
hACC2-IN-1 shows good potency against the human ACC2 (hACC2) enzyme^[1].

分子量

432.58

Formula

C₂₃H₃₂N₂O₄S

CAS 号

192323-14-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.