Zeaxanthin dipalmitate (Physalien) 是一种枸杞衍生的类胡萝卜素，具有抗炎和抗氧化应激作用。Zeaxanthin dipalmitate 与p2X7受体 (Kd=81.2 nM) 和脂联素受体 1 (AdipoR1;Kd=533 nM) 以正剂量依赖性方式直接相互作用。Zeaxanthin dipalmitate 恢复乙醇中毒抑制的线粒体自噬 (autophagy) 功能。Zeaxanthin dipalmitate 可用于酒精性脂肪肝 (AFLD)、色素性视网膜炎 (RP) 的研究。
| 生物活性 | Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact withp2X7 receptor(Kd=81.2 nM) andadiponectin receptor1(AdipoR1;Kd=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrialautophagyfunctions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP)[1][2]. |
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体外研究
(In Vitro) | Zeaxanthin dipalmitate (1 μM; 2 h) totally or partially reverses the down-regulation of Atg5, beclin-1, and LC3A/B by ethanol (250 mM), and the up-regulation of p62 by ethanol in BRL-3A cells[1].
Zeaxanthin dipalmitate (1 μM; 2 h) partially recovers the ethanol-suppressed LC3B in BRL-3A cells[1].
Zeaxanthin dipalmitate (1 μM; 2 h) partially recovers the ethanol-suppressed cell viability and ethanol-induced aspase-3/7 activity of BRL-3A cells[1].
Zeaxanthin dipalmitate (1 μM; 2 h) recovers the ethanol-induced inhibition of mitophagy in BRL-3A cells[1].
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体内研究
(In Vivo) | Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) reduces the serum ALT and AST levels increased by long-term ethanol challenge in at AFLD Model[1].
Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) effectively attenuates the histological injury[1].
Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) attenuates the AFLD-induced hepatic apoptosis (reveal by caspase-3/7 activity) and inflammation (TNF-α) in rat[1].
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the visual behavior of rd10 mice and delays the degeneration of retinal photoreceptors[2].
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the light responses of photoreceptors, bipolar cells and retinal ganglion cells[2].
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) reduces the expression of genes that are involved in inflammation, apoptosis and oxidative stress in rd10 mice[2].
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| 来源 | - Plants
- Solanaceae
- Lycium chinenseMiller
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
