Leu-AMS

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Leu-AMS

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

288591-93-5

Leu-AMS (compound 6)，亮氨酸类似物，是一种有效的亮氨酰-tRNA 合成酶 (LRS) 抑制剂，IC₅₀值为 22.34 nM，Leu-AMS 抑制了LRS 的催化活性，但不影响亮氨酸诱导的 mTORC1 活化。Leu-AMS在癌细胞和正常细胞中显示出细胞毒性，并抑制细菌的生长。

生物活性

Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor ofleucyl-tRNA synthetase(LRS) with anIC₅₀of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-inducedmTORC1activation. Leu-AMS shows cytotoxicity incancercells and normal cells, and inhibits the growth of bacteria^[1].

IC₅₀& Target

IC50: 22.34 nM (LRS)^[1]

体外研究
(In Vitro)

Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC₅₀value of 22.34 nM. Leu-AMS is highly cytotoxic in both cancer cells and normal cells. Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all. Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation^[1].

分子量

459.48

性状

Solid

Formula

C₁₆H₂₅N₇O₇S

CAS 号

288591-93-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 49.17 mg/mL(107.01 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.1764 mL	10.8819 mL	21.7637 mL
5 mM	0.4353 mL	2.1764 mL	4.3527 mL
10 mM	0.2176 mL	1.0882 mL	2.1764 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。