| CAS NO: | 53467-23-5 |
| 包装 | 价格(元) |
| 500μg | 询价 |
| 1mg | 询价 |
| Cas No. | 53467-23-5 |
| 别名 | (3S)-3-羟基奎尼定 |
| Canonical SMILES | COC1=CC=C2C(C([C@H](O)[C@@]3([H])C[C@H]4[C@](C=C)(O)C[N@@]3CC4)=CC=N2)=C1 |
| 分子式 | C20H24N2O3 |
| 分子量 | 340.4 |
| 溶解度 | Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner. |
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