H-Tyr-Tyr-OH

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H-Tyr-Tyr-OH

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1050-28-8

L-Tyrosyl-L-tyrosine

H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) 是一种降压肽。H-Tyr-Tyr-OH 抑制血管紧张素转换酶 (ACE)，IC₅₀值为 0.028 mg/mL。H-Tyr-Tyr-OH 可用于高血压的研究。

生物活性

H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme (ACE) with anIC₅₀value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure^[1]^[2].

IC₅₀& Target

IC50: 0.028 mg/mL (ACE)^[2]

体外研究
(In Vitro)

H-Tyr-Tyr-OH shows inhibitory effect against ACE with an IC₅₀value of 0.028 mg/mL^[2].

体内研究
(In Vivo)

H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo^[1].
H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats^[1].

Animal Model:	Anesthetized male SpragueDawley rats^[1]
Dosage:	12.5 mg/kg
Administration:	Intraarterial injection; 12.5 mg/kg once
Result:	Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration.

Animal Model:	Spontaneously hypertensive rats^[1]
Dosage:	0, 50 and 100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg.

分子量

344.36

性状

Solid

Formula

C₁₈H₂₀N₂O₅

CAS 号

1050-28-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)