Fosinopril Sodium is the ester prodrug of anangiotensin-converting enzyme (ACE)inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

IC₅₀: 0.18 μM; Ki: 1.675 μM

Fosinopril (0, 1, 10, 33, 100μM; 30 min) partially inhibits the cosedimentation of liposomes and recombinant LPLA2^[1].
Fosinopril (250 nM) shows no inhibition of the soluble esterase activity of LPLA2^[1].
Fosinopril (0.372, 0.744, 1.116 μM) displays a non-competitive inhibition effect on ACE activity with a K_ivalue of 1.675 μM^[2].

Fosinopril (orally; 4.67 mg/kg; 4 weeks) downregulates the creatine kinase (CK) and lactate dehydrogenase (LDH) levels and against cardiac dysfunction and structural alteration^[3].
Fosinopril (orally; 4.67 mg/kg; 4 weeks) suppresses cleaved-caspase 3 expression and myocardial apoptosis in AMI rat model^[3].

585.64

Solid

C₃₀H₄₅NNaO₇P

88889-14-9

福辛普利钠

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : 33.33 mg/mL(56.91 mM;Need ultrasonic)

Ethanol : 16.67 mg/mL(28.46 mM;Need ultrasonic)

DMSO : 1.43 mg/mL(2.44 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 9.09 mg/mL (15.52 mM); Clear solution; Need ultrasonic